Diagnosing aHUS

Atypical Haemolytic Uremic Syndrome (aHUS) can be difficult to diagnose because it is a rare disease and has a wide range of symptoms that are similar to those of other diseases, including fatigue or tiredness, pale skin and sleepiness or drowsiness.1-4 Kidney failure is one of the most common symptoms, which can be one of the early signs that help diagnose aHUS.3,4

Doctors will assess a patient’s symptoms and perform a number of different tests to exclude the possibility of other diseases and to confirm the diagnosis of aHUS.1-3,5

How can aHUS be diagnosed?

To establish an accurate diagnosis of aHUS, a number of tests may be performed.1–3,5 Some of these potential tests are listed below:

A healthcare professional will review a patient’s blood count to determine the number of red blood cells and platelets.1–3,5

A healthcare professional will review a patient’s blood count to determine the number of red blood cells and platelets.1–3,5

Blood tests can help in assessing the organ involvement and high level of the enzyme lactate dehydrogenase (LDH) which indicates increased haemolysis.1–3,5

A healthcare professional will review a patient’s kidney function by measuring the level of a protein called creatinine and determining the estimated glomerular filtration rate (eGFR). These tests can indicate how well the kidneys are working.1–3,5

Detecting aHUS early makes managing and treating the condition easier, and may lead to better outcomes.

If you spot any of the symptoms above, speak to your doctor.

aHUS, atypical haemolytic uremic syndrome; TMA, thrombotic microangiopathy.

References: 1. Raina R, et al. Cells. 2021;10:3580. 2. Avila Bernabeu AI, et al. Nephron. 2020;144:537–49. 3. Yerigeri K, et al. J Multidiscip Healthc. 2023;16:2233–49. 4. Yan K, et al. Clin Epidemiol. 2020;12:295–305. 5. Formeck C, et al. Pediatr. Nephrol. 2019;34:1337–48.

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